The MendelianRandomization R package was recently updated to version v0.2.2. There were some fixes in terms of p-values and confidence intervals (for example, previously p-values were based on a t-distribution regardless of the choice specified by the user). The package can be downloaded from https://cran.r-project.org/web/packages/MendelianRandomization/index.html. A paper introducing the package can be found at https://www.ncbi.nlm.nih.gov/pubmed/28398548.